LIMMS, the Laboratory for Integrated Micro Mechatronic Systems, celebrated its 20th anniversary in 2015. Since its creation in 1995 it has hosted more than 430 researchers from France and other countries. Since 2004, it became a CNRS UMI (UMI 2820). Its field of research can roughly be grouped into three axes. Nanotechnology, advanced MEMS and bio-MEMS. In 2016 LIMMS direction has highlighted 4 general fields of applications related to BioMEMS for translational research, Integrative Bioengineering, Energy, and Smart sensors in society. LIMMS aims to combine expertise of both Japanese and French researchers and to explore new frontiers in the three highly interdisciplinary fields. In 2014, LIMMS inaugurated a mirror platform in Lille (France), through the SMMIL-E project Seeding Microsystems in Medicine in Lille-European Japanese technologies against cancer. LIMMS conducts cutting-edge research in interdisciplinary research fields by pioneering a variety of fields and conducting a wide range of collaborative research based on its core advanced nano- and micro-device fabrication technology.