New method expertly evaluates protein folding stability on a large scale

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Researchers at Northwestern University and recently joining the Institute for Industrial Science, The University of Tokyo developed a method to evaluate the folding stability of a million proteins simultaneously. DNA libraries were used to generate protein-DNA complexes that were treated with enzymes to destroy unfolded proteins. The intact proteins were identified by DNA sequencing. This system can describe the factors that keep protein structure and advance our understanding of diseases involving protein misfolding.

2023.07.20

Press Release

New method expertly evaluates protein folding stability on a large scale

Researchers from Northwestern University and recently joining the #UTokyo_IIS develop a high-throughput approach to evaluate protein folding stability in thousands of proteins.

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