In recent years, a great deal of research has been conducted on creating organ models known as organoids. Organoids are produced by differentiating stem cells or iPS cells into the cells of a target organ while culturing them in three dimensions, thereby partially replicating cell-to-cell interactions and certain functions of the organ. Brain-mimicking organoids have also been developed and are drawing attention as a new approach to neuroscience research. At #UTokyo_IIS, Professor Yoshiho Ikeuchi is taking an inventive approach to brain organoid research, employing unique methods to uncover the secrets behind the intricate workings of the human brain.