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Blood Runs Deep: Lab Blood Vessel Model Sheds Light on Angiogenesis
Blood Runs Deep: Lab Blood Vessel Model Sheds Light on Angiogenesis


Researchers at The University of Tokyo and at CNRS in France revealed the importance of the molecule EGFL7 for angiogenesis and endothelial integrity using an artificially created blood vessel model called a microvessel-on-a-chip. They showed that EGFL7 knockdown in the endothelial cells forming this model resulted in reduced angiogenesis and impaired barrier function. This work suggested the value of targeting EGFL7 and of using the microvessel-on-a-chip in the pursuit of treatments for diseases like cancer and diabetic retinopathy.