In vitro cancer model reveals how tumor cells access the bloodstream

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がん-微小血管チップでがん転移過程の一部を可視化（1200_800）.jpg

Researchers from the Institute of Industrial Science, The University of Tokyo, developed a tumor-microvessel on-a-chip system and demonstrated that clusters of circulating tumor cells, after detaching from primary tumors, disrupt blood-vessel walls by inducing endothelial-to-mesenchymal transition. The clusters then enter the bloodstream and establish distal metastases. Targeting the ability of these clusters to disperse could help treat patients with advanced metastatic cancer.

2025.05.22

Press Release

In vitro cancer model reveals how tumor cells access the bloodstream

Researchers from #UTokyo_IIS detail how clusters of cells detach from primary tumors and penetrate blood-vessel walls to enter the bloodstream, enabling them to establish distal metastases.

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