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Blood vessel-on-a-chips show anti-cancer drug effects in human cells
Blood vessel-on-a-chips show anti-cancer drug effects in human cells

Researchers at the Institute of Industrial Science, the University of Tokyo, and LIMMS/CNRS-IIS a joint French - Japanese research laboratory between the CNRS and the University of Tokyo, report new organ-on-a-chip technology to observe sprouting angiogenesis from a single blood vessel. VEGF stimulated new capillaries from the single vessel by activating NOTCH signaling, recapitulating biochemical events of the human angiogenesis. The chip also confirmed the effects of two FDA-approved anti-angiogenic drugs, demonstrating its applicability to drug discovery.